Active ingredients: ternidazole - 0.2 g, neomycin sulfate - 0.1 g or 65000 IU, nystatin - 100 000 IU, prednisolone sodium metasulfobenzoate - 0.0047 g, equivalent to prednisolone - 0.003 g.
Excipients: wheat starch - 0.264 g, lactose monohydrate - q.s. up to 1.2 g, colloidal silicon dioxide - 0.006 g, magnesium stearate - 0.01 g, sodium carboxymethyl starch - 0.048 g
Combined preparation for topical use in gynecology. It has antimicrobial, anti-inflammatory, antiprotozoal, antifungal effects; ensures the integrity of the vaginal mucosa and a constant pH.
Ternidazole is an antifungal agent from the group of imidazole derivatives, reduces the synthesis of ergosterol (an integral part of the cell membrane), changes the structure and properties of the cell membrane. It has a trichomonacid effect, it is also active against anaerobic bacteria, in particular gardnerella.
Neomycin is a broad-spectrum antibiotic from the group of aminoglycosides. It acts bactericidal against gram-positive (Staphylococcus, Streptococcus pneumoniae) and gram-negative (Escherichia coli, Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Proteus spp.) Microorganisms; against Streptococcus spp., inactive.
The resistance of microorganisms develops slowly and to a small extent.
Nystatin is an antifungal antibiotic from the group of polyenes, highly effective against yeast-like fungi of the genus Candida, changes the permeability of cell membranes and slows their growth.
Prednisone is a dehydrogenated analog of hydrocortisone, has a pronounced anti-inflammatory, anti-allergic, anti-exudative effect.
Treatment of vaginitis caused by microorganisms sensitive to the drug, including:
vaginitis caused by fungi of the genus Candida;
Prevention of vaginitis, including:
before gynecological operations;
before childbirth and abortion;
before and after the installation of intrauterine devices;
before and after diathermocoagulation of the cervix;
Pregnancy and lactation
It is possible to use Terzhinan during pregnancy and during lactation (breastfeeding) according to indications.
Hypersensitivity to the components of the drug.
Burning sensation, itching and irritation in the vagina (especially at the beginning of treatment).
In some cases, allergic reactions are possible.
How to take, course of administration and dosage
For vaginal use. One tablet is injected deep into the vagina in the prone position before bedtime. Before insertion into the vagina, the tablet should be held in water for 20-30 seconds. After administration, lie down for 10 to 15 minutes. The average duration of a treatment course of therapy is 10 days; in case of confirmed mycosis, it can be increased up to 20 days; the average duration of the preventive course is 6 days.
Due to the low degree of absorption into the systemic circulation, an overdose is unlikely.
It is necessary to conduct simultaneous treatment of the sexual partner because of the danger of re-infection.
Store at room temperature.