Amoxicillin, 500 mg, 16 pcs.

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Product Description


The active substance  is amoxicillin 500.00 mg (in the form of amoxicillin trihydrate 573.9 mg);

excipients  - magnesium stearate 9.20 mg,

microcrystalline cellulose PH 102 - 26.90 mg;

capsule number 0:

gelatin up to 96 mg;

capsule cap:

titanium dioxide [E 171] - 0.49920 mg,

dye sunny sunset yellow [E 110] - 0.13774 mg,

dye azorubine [E 122] - 0.13336 mg;

capsule body:

titanium dioxide [E 171] - 0.57600 mg,

iron oxide yellow oxide [E 172] 0.26899 mg.

pharmachologic effect

Amoxicillin is a broad-spectrum antibiotic from the group of semi-synthetic penicillins with a wide spectrum of action. 

The effect of amoxicillin occurs very quickly. Like other penicillin antibiotics, it inhibits cell wall synthesis. 

Amoxicillin is bactericidal and active against gram-positive cocci (Staphylococcus spp., Streptococcus pneumoniae, group A, B, C, G, H, I, M streptococci); Gram-negative cocci (Neisseria meningitidis, 

N. gonorrhoeae); gram-negative rods (Escherichia coli, Shigella spp., Klebsiella spp., Proteus mirabilis, Salmonella, Campilobacter, Haemophilus influenzae, Bordetella pertussis, Chlamydia). 

Amoxicillin is active against all microorganisms sensitive to penicillin G: Erysipelothrix rhysiopathiae, Corynebacterium, Bacillus anthracis, Actinomycetes, Streptobacilli, Spirillium minus, Pastereulla multocida, Listeria, Spirochaetlia) and Leptira Borotema. 

as well as various anaerobic microorganisms (including peptococci, peptostreptococci, clostridia and fusobacteria). 

The strains of microorganisms producing beta-lactamases are resistant to Amoxicillin. 

Amoxicillin is acid resistant and therefore effective for oral use.


Infectious and inflammatory diseases caused by microorganisms sensitive to amoxicillin:

  • upper respiratory tract infections (tonsillopharyngitis, sinusitis, acute otitis media);
  • lower respiratory tract infections (acute bacterial bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia);
  • infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, endometritis, cervicitis, gonorrhea);
  • abdominal infections (cholangitis, cholecystitis);
  • Helicobacter pylori eradication in patients with peptic ulcer of the stomach and duodenum (always in combination with other drugs);
  • infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses);
  • leptospirosis, listeriosis;
  • Lyme disease
  • gastrointestinal tract infections (enterocolitis, typhoid fever, dysentery, salmonellosis caused by Salmonella typhi sensitive to ampicillin, salmonella carriage;
  • prevention of bacterial endocarditis during surgical procedures in the oral cavity and upper respiratory tract.

Pregnancy and lactation

Data on the possible embryotoxic, teratogenic or mutagenic effects of the drug when taken during pregnancy are currently not available.

Amoxicillin is found in breast milk, which should be considered when prescribing Amoxicillin during lactation.


  • Hypersensitivity to amoxicillin, other beta-lactam antibiotics (other penicillins, cephalosporins, monobactam, carbapenems) or any components of the drug;
  • infectious mononucleosis, lymphocytic leukemia;
  • children's age up to 3 years (for this dosage form).
With caution:

Allergic reactions (including bronchial asthma, hay fever, hypersensitivity to acetylsalicylic acid) in the anamnesis, a history of gastrointestinal tract diseases (especially colitis associated with the use of antibiotics), renal failure, pregnancy and the period of breastfeeding .

Side effects

Allergic reactions: 

urticaria, skin rash, erythema, exanthema, Quincke edema, rhinitis, conjunctivitis, photosensitivity; rarely - fever, joint pain, eosinophilia; in isolated cases - anaphylactic shock.


perhaps the development of superinfection with the appearance of loose stools, nausea.


Antacids, glucosamine, laxatives, aminoglycosides - slow down and reduce the absorption of amoxicillin; ascorbic acid enhances absorption.

Ethanol reduces the rate of absorption of amoxicillin.

Amoxicillin enhances digoxin absorption.

Probenecid, competing for the excretion route, slows down the elimination of amoxicillin, which leads to an increase in the concentration of amoxicillin in blood plasma. Amoxicillin likewise interacts with diuretics, non-steroidal anti-inflammatory drugs (oxyphenbutazone, phenylbutazone, acetylsalicylic acid, indomethacin).

Amoxicillin helps reduce the clearance of methotrexate, which can lead to the development of toxic effects of the latter.

With the simultaneous administration of allopurinol, the risk of developing skin allergic reactions increases.

Amoxicillin, suppressing the intestinal microflora, helps to reduce the synthesis of vitamin K and the prothrombin index, which increases the effectiveness of indirect anticoagulants and drugs, during the metabolism of which para-aminobenzoic acid is formed, which ultimately increases the risk of bleeding “breakthrough”.

Amoxicillin reduces the effectiveness of oral contraceptives, since under the conditions of an altered intestinal biocenosis, estrogen reabsorption decreases.

With the combined use of amoxicillin with bactericidal antibiotics (aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), a synergistic antibacterial effect is observed. Bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides), on the contrary, weaken the bactericidal effect of amoxicillin.

Metronidazole increases the antibacterial activity of amoxicillin.

How to take, course of administration and dosage

Adults are prescribed 500 mg 3 times / day. 

In severe cases of the disease - 1 g 3 times / day.

Children aged 5-10 years are prescribed 250 mg 3 times / day, children 2-5 years old - 125 mg 3 times / day, children under 2 years old - at the rate of 20 mg / kg body weight (divided into 3 doses). 

The course of treatment is 5-12 days. The interval between doses is 8 hours. 

For the treatment of acute uncomplicated gonorrhea, 3 g is prescribed once (in combination with 1 g of probenecid). 

Women are recommended to repeat the specified dose in a day.

Special instructions

In patients with hypersensitivity to cephalosporins, carbapenems, the possibility of cross-allergy should be considered. 

In severe infections of the gastrointestinal tract, accompanied by constant diarrhea or vomiting, amoxicillin should not be administered orally due to the possibility of poor absorption. 

The use of antibiotics is ineffective in the treatment of acute respiratory viral infections.

Particular care should be taken in patients with allergic diathesis or bronchial asthma and hay fever (hay fever), a history of gastrointestinal diseases (especially colitis associated with the use of antibiotics). 

With long-term administration of Amoxicillin, nystatin, levorin, or other antifungal drugs should be prescribed simultaneously.

With prolonged use of high doses of the drug in patients, liver and kidney function indicators should be monitored, general urinalysis performed. It is advisable to control the picture of peripheral blood.

Release form


Storage conditions

Store in a dry, dark place at room temperature. 

Shelf life

2 years.

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