1 tablet contains:
betahistine dihydrochloride 16 mg;
lactose (milk sugar);
citric acid monohydrate;
colloidal silicon dioxide (aerosil);
Betahistine is a histaminergic that improves microcirculation.
An agonist of H1 receptors of the vessels of the inner ear and an antagonist of H3 receptors of the vestibular nuclei of the central nervous system. By direct agonistic action on the H1 receptors of the vessels of the inner ear, as well as indirectly through action on the H3 receptors, it improves microcirculation and capillary permeability, normalizes the pressure of the endolymph in the labyrinth and cochlea, and increases blood flow in the basilar artery.
It has a pronounced central effect, being an inhibitor of the H3 receptors of the nuclei of the vestibular nerve. Improves the conductivity in the neurons of the vestibular nuclei at the level of the brain stem.
The clinical manifestation of these properties is a decrease in the frequency and intensity of dizziness, a decrease in tinnitus, and an improvement in hearing if it is reduced.
It is absorbed quickly, binding to plasma proteins is low. The time required to reach Cmax is 3 hours.
It is almost completely excreted by the kidneys in the form of a metabolite (2-pyridylacetic acid) within 24 hours. T1 / 2 - 3-4 hours.
- treatment and prevention of vestibular dizziness of various origins
- syndromes including dizziness and headache, tinnitus, progressive hearing loss, nausea and vomiting
- Meniere's disease or syndrome.
Pregnancy and lactation
There is not enough data to assess the effects of the drug during pregnancy and lactation.
In this regard, it is not recommended to take during pregnancy.
At the time of treatment, it is necessary to stop breastfeeding.
- hypersensitivity to any of the components of the drug;
- lactose intolerance;
- lactase deficiency or glucose-galactose malabsorption;
- age up to 18 years;
- lactation period.
- peptic ulcer of the stomach and duodenum (history);
- bronchial asthma.
Gastrointestinal disorders, allergic reactions from the skin (skin rash, itching, urticaria), Quincke edema.
At the same time, antihistamines reduce the effect of betahistine.
How to take, course of administration and dosage
Inside, while eating. 1 / 2-1 tablets 3 times a day.
Improvement is usually noted already at the beginning of therapy.
A stable therapeutic effect occurs after two weeks of treatment and can increase over several months of treatment. The treatment is long. The duration of the drug is selected individually.
Symptoms: nausea, vomiting, cramps.
Treatment: gastric lavage, intake of activated carbon, symptomatic therapy.
Caution should be used in patients with a history of gastric or duodenal ulcer, in the history, in the second and third trimesters of pregnancy, as well as in children.
It must be borne in mind that the desired clinical effect is achieved after several months of treatment.
For dyspeptic symptoms, betahistine is recommended to be taken during or after meals.