Chloramphenicol 3% Renewal bottle, 25 ml

(0) Write a Review

Product Description


100 ml of the solution contain:
Active substance:
Chloramphenicol -1 g; 3 g.
ethanol (ethyl alcohol) - up to 100 ml, 70%

pharmachologic effect

A bacteriostatic broad-spectrum antibiotic disrupts the process of protein synthesis in a microbial cell (having fat solubility, penetrates the bacterial cell membrane and reversibly binds to the 50S subunit of bacterial ribosomes, in which the movement of amino acids to the growing peptide chains is delayed, which leads to disruption of protein synthesis). 

Effective against strains of bacteria resistant to penicillin, tetracyclines, sulfonamides. Active against Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, some species of Enterobacter and Neisseria, Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus haemolyticus), Moraxella lacunata, rickettsia and mycoplasmas. 

Not effective against acid resistant bacteria, anaerobes, Acinetobacter spp., Pseudomonas aeruginosa, Serratia marcescens.


During instillation of the drug into the conjunctival sac, therapeutic concentrations are created in the aqueous humor of the eye, cornea, iris, vitreous humor; does not penetrate the lens. Partially enters the systemic circulation. It is excreted mainly by the kidneys in the form of inactive metabolites, partly by the intestines.


Bacterial skin infections caused by susceptible microorganisms, including infected burns (superficial and limited deep), pressure sores, trophic ulcers, wounds, boils.

Pregnancy and lactation

The use of the drug is contraindicated during pregnancy and during breastfeeding.


Increased individual sensitivity to the components of the drug; inhibition of bone marrow hematopoiesis; acute intermittent porphyria; glucose-6-phosphate dehydrogenase deficiency; hepatic and / or renal failure; pregnancy, lactation; neonatal period (up to 4 weeks).

Skin diseases (psoriasis, eczema, fungal infections); early childhood; patients previously treated with cytostatic drugs or radiation therapy.

Side effects

Local allergic reactions. With prolonged use: reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythrocytopenia; rarely - aplastic anemia, agranulocytosis; secondary fungal infection.


Simultaneous administration with drugs that inhibit hematopoiesis (sulfonamides, cytostatics), affecting the metabolism in the liver, or radiation therapy increases the risk of side effects. 

With simultaneous use with erythromycin, clindamycin, lincomycin, a mutual weakening of action is noted due to the fact that chloramphenicol can displace these drugs from a bound state or prevent their binding to the 50S subunit of bacterial ribosomes. 

When prescribed with oral hypoglycemic drugs, an increase in their action is noted due to the suppression of metabolism in the liver and an increase in their concentration in plasma. Chloramphenicol suppresses the enzyme system of cytochrome P450, therefore, with the simultaneous use of phenobarbital, phenytoin, indirect anticoagulants, a weakening of the metabolism of these drugs, a slowdown in excretion, and an increase in their concentration in plasma are noted. 

Reduces the antibacterial effect of penicillins and cephalosporins.

How to take, course of administration and dosage

Outwardly. Damaged areas are treated with a cotton swab dipped in a solution several times a day.


With prolonged use, as well as with the use of high doses of the drug, patients may develop irritation of the skin and mucous membranes, as well as local allergic reactions, including skin rash, itching and urticaria.
In isolated cases, the development of edema and hyperemia at the site of the use of high doses of the drug was noted.
With the development of symptoms of overdose, the dose of the drug should be reduced, if the patient does not show improvement after lowering the dose, the drug is canceled.

Special instructions

There is some information about the development of bone marrow hypoplasia after the use of ophthalmic forms (during treatment, systematic monitoring of the peripheral blood picture is necessary).
After opening, use within 14 days.

Storage conditions

The drug is recommended to be stored in a dry place away from direct sunlight at a temperature of 8 to 15 degrees Celsius.

Shelf life

2 years.

Customers Also Viewed

Chondroxide, 5%, 30 g

Nizhpharm, Russia


Composition 100 g of ointment contains: Active substance:  Chondroitin sulfate (in terms of dr…