Clotrimazole Cream 1%, 20 g

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Product Description


100 g of cream contain:

active substance:

clotrimazole 1.0 g


benzyl alcohol,

cetasteryl alcohol

eutanol G (2-octylododecanol),

polysorbate 60,

Span 60 (sorbitan stearate),

synthetic olbrot (synthetic spermaceti),

purified water

Description: Homogeneous mass of white color.

pharmachologic effect

Clotrimazole is a broad-spectrum antifungal agent for topical application. The antimycotic effect of the active substance (imidazole derivative) is associated with impaired synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis.

It acts fungistatically in small concentrations, and fungicidal in large concentrations, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Effective against dermatophytes, yeast-like and mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor (Malazessia furfur) and the causative agent of erythrasma. It has an antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Bacteroides, Gardiierella vaginalis), as well as against Trichomonas vaginalis.


Clotrimazole is poorly absorbed through the skin and mucous membranes and has virtually no systemic effect. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes. For external use, the concentration of clotrimazole in the epidermis is higher than in the dermis and subcutaneous tissue.


  • fungal skin diseases, mycoses of skin folds, feet;
  • pityriasis versicolor, erythrasma, superficial kaidosis caused by dermatophytes, yeast (including the genus Candida), mold and other fungi and pathogens sensitive to clotrimazole;
  • mycoses complicated by secondary pyoderma.

Pregnancy and lactation

It should not be used in the first trimester of pregnancy (adequate and strictly controlled studies have not been conducted).

With intravaginal use in women in the II and III trimesters of pregnancy, an adverse effect on the fetus was not detected, however, the use of a vaginal applicator is undesirable.

With caution - during breastfeeding (it is not known whether clotrimazole passes into breast milk).


Hypersensitivity to clotrimazole or excipients, I trimester of pregnancy.

With caution - lactation.

Side effects

Itching, burning, tingling in the places of applying the cream, the appearance of erythema, blisters, swelling, irritation and peeling of the skin. Allergic reactions (itching, urticaria).


Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole with simultaneous use.

When applying the cream, negative interactions with other agents are not known and should not be expected, because the resorption capacity of clotrimazole is very low.

How to take, course of administration and dosage

Outwardly. The cream is applied in a thin layer 2-3 times a day on previously cleaned (using soap with a neutral pH value) and dry affected areas of the skin and gently rubbed.

The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy.

Treatment of dermatomycosis is carried out for at least 4 weeks, pityriasis versicolor -1-3 weeks.

In case of fungal diseases of the foot rut, therapy is recommended to be continued for at least 2 weeks after the symptoms of the disease have been eliminated.


The use of cream in high doses does not cause any reactions and conditions that are life-threatening.

Special instructions

Application of the drug to the skin in the eye area is not recommended. In patients with hepatic insufficiency, the functional state of the liver should be periodically monitored.

When signs of hypersensitivity or irritation appear, treatment is discontinued.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Release form

Cream for external use

Storage conditions

At a temperature below 25 °, out of the reach of children.

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