1 ml of solution contains:
bacterial lipopolysaccharide for intramuscular administration;
phosphate buffered saline (pH = 6.7-7.3)
Pyrogenal is a broad-spectrum immunomodulator, the main of which are the activation of the reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. Pyrogenal possesses adjuvant, desensitizing and anti-inflammatory properties, increases the general and specific resistance of the body, affects the thermoregulatory centers of the hypothalamus.
The drug, stimulating the cells of the phagocytic system, activates phagocytosis, the secretion of oxygen radicals, the synthesis of interleukin-1 (IL-1, IL-2), tumor necrosis factor (TNF L), interferon (IFN L). Acting on fibroblasts, it interferes with the synthesis of collagen by fibroblasts, accelerates the maturation of fibrocytes.
Stimulates the activity of hyaluronidase: it provides an increase in tissue permeability, an improvement in the fibrinolytic properties of blood, restoration of blood circulation, prevents the formation of new ones and dissolves previously formed dense scars and adhesions, prevents vascular obliteration, stimulates tissue regeneration and epithelization.
It activates the function of the adrenal cortex: it has an anti-inflammatory effect, increases the concentration of hormones in the blood. Stimulates the kinin system.
- chronic liver disease;
- strictures of the urethra, ureters, chronic prostatitis, urethritis;
- trauma to the central nervous system and peripheral nervous system;
- tuberculosis (torpid form in the resorption phase);
- uveitis, iridocyclitis, herpes eye infection, corneal opacity;
- inflammation of the uterine appendages, infertility;
- adhesive disease of the abdominal cavity;
- burn disease;
- venereal diseases;
- psoriasis and other chronic skin diseases.
Application during pregnancy and lactation
Contraindicated in pregnancy and lactation.
- blood diseases;
- acute febrile diseases;
- chronic diseases in the stage of exacerbation and decompensation (with the exception of diseases that are an indication for the administration of the drug);
With care: diseases of the cardiovascular system, kidneys, diabetes mellitus, lowering the seizure threshold, convulsions, febrile convulsions.
Hyperthermia up to 37.5 ° C, accompanied by mild chills and slight malaise. This state can last from 3 to 8 hours. In this case, the dose that caused a similar reaction is repeated in the following days until the reaction to its introduction stops (usually 1-3 injections), after which the dose is sequentially increased.
In rare cases, individuals may experience severe chills, fever up to 39.5 ° C, headache, back pain. These reactions usually last from 6 to 8 hours, after which the temperature decreases and the side effects disappear. In these cases, it is recommended to reduce the dose of the drug.
When using the drug for pyrotherapy, the above reactions are permissible.
The drug is compatible and well combined with all drugs used in the treatment of diseases and conditions indicated in the indications.
Enhances the effectiveness of chemotherapy drugs as part of complex therapy.
How to take, course and dosage
In / m 1 time / day every other day, if necessary, the drug is diluted with 0.9% sodium chloride solution.
The initial single dose is 0.2 mcg, on the following days the dose is gradually increased by 2.5-5 mcg.
The maximum single dose is 100 mcg. Full course - 10-30 injections, if necessary, repeat the course - in 2-3 months.
For pyrotherapy - i / m 1 time / day, starting from 5-10 mcg with an increased dose increase up to 100-150 mcg. Injections are carried out in 1-2 days.
If, with intramuscular administration, hyperthermia, chills, malaise usually occur within 3-8 hours, then the dosage that caused a similar reaction is repeated on subsequent days (usually 1-3 days) until the reaction stops, after which the dose is sequentially increased.
In the presence of convulsive readiness, the drug is prescribed against the background of anticonvulsant therapy.
Solution for i / m administration