The drug is a phagolysate filtrate that is active against staphylococcal bacteria of the most common phage types, incl. staphylococcus aureus.
Staphylococcal bacteriophage - immunobiological preparation, phage.
Staphylococcal bacteriophage has the ability to specifically lyse staphylococcal bacteria isolated during purulent infections, incl. Staphylococcus aureus.
Staphylococcal bacteriophage is used for the treatment and prevention of purulent infections of the skin, mucous membranes, visceral organs caused by staphylococcal bacteria, as well as for dysbacteriosis:
- diseases of the ear, throat, nose, respiratory tract and lungs (sinusitis, otitis media, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
- surgical infections (purulent wounds, infected burns, abscess, phlegmon, furuncle, carbuncle, hydradenitis, panaritium, infiltrated and abscessed staphylococcal sycosis, paraproctitis, mastitis, bursitis, tendovaginitis, osteomyelitis);
- urogenital pathology (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis);
- enteric pathology (gastroenterocolitis, cholecystitis, intestinal dysbiosis);
- generalized septic diseases;
- purulent-inflammatory diseases of newborns (omphalitis, gastroenterocolitis, sepsis);
- other diseases of staphylococcal etiology;
- prevention of purulent processes in freshly infected wounds (operations of the abdominal and chest cavity, street and industrial injuries, etc.); for the prevention of nosocomial infections for epidemic indications.
Reactions to the introduction of staphylococcal bacteriophage have not been established.
When injected intradermally, there may be rapidly transient reversible redness and inflammation.
The use of staphylococcal bacteriophage does not exclude the use of other drugs.
Combined treatment with staphylococcal bacteriophage in combination with antibiotics can be performed.
How to take, course of administration and dosage
An important condition for effective phage therapy is a preliminary determination of the phage sensitivity of the pathogen (determination of the sensitivity of strains isolated from the patient to the staphylococcal bacteriophage).
The staphylococcal bacteriophage is introduced into the focus of infection. The duration of the course of treatment is 5-15 days. Doses and route of administration depend on the nature of the focus of infection (locally in the form of irrigation, lotions and tamponation; intradermally; in the cavity - abdominal, pleural, articular; into the bladder through a catheter; per os and per rectum). With a recurrent course of the disease, repeated courses of treatment are possible.
Topically in the form of irrigation, lotions and tamponing with liquid phage in an amount of up to 200 ml, taking into account the size of the affected area, or lubrication with ointment.
Treatment of pyoinflammatory diseases with localized lesions is advisable to be carried out simultaneously both locally and by mouth for 7-20 days.
For purulent-inflammatory diseases of the ear, throat, nose, staphylococcal bacteriophage is administered in a dose of 2-10 ml 1-3 times a day; used for rinsing, rinsing, instillation, introduction of moistened turundas (leaving them for 1 hour).
With boils and carbuncles, liquid staphylococcal bacteriophage is injected directly into the focus or under the base of the infiltrate, as well as around it. Injections are made every day, every other day, depending on the reaction, in sequentially increasing doses: for 1 injection - 0.5 ml, then 1 - 1.5 - 2 ml. In total, 3-5 injections are performed per treatment cycle.
In case of abscesses, staphylococcal bacteriophage is injected into the cavity of the focus after puncture removal of pus. The amount of injected drug should be slightly less than the volume of removed pus. When opening an abscess, a tampon is introduced into the cavity, abundantly moistened with staphylococcal bacteriophage.
In chronic osteomyelitis, staphylococcal bacteriophage is injected into the wound immediately after its surgical treatment.
For the treatment of deep forms of pyoderma, staphylococcal bacteriophage is used intradermally in small doses of 0.1-0.5 ml in one place or, if necessary, up to 2 ml in several places. Only 10 injections every 24 hours.
Introduction into the cavity - abdominal, pleural, articular and others up to 100 ml of bacteriophage. Capillary drainage is left, through which the bacteriophage is re-injected every other day, only 3-4 times.
With cystitis, a staphylococcal bacteriophage is introduced into the bladder cavity using a catheter.
With purulent pleurisy, bursitis or arthritis, staphylococcal bacteriophage is injected into the cavity after removing pus from it in an amount of up to 20 ml. and more, every other day, 3-4 times.
Inside, in the form of tablets, staphylococcal bacteriophage is used to treat urogenital infectious pathology - cystitis, pyelitis, pyelonephritis, endometritis, salpingo-oophoritis, enteric infections and other diseases caused by staphylococcus bacteria.
In intestinal forms of the disease caused by staphylococcus and intestinal dysbiosis, liquid staphylococcal bacteriophage is used: inside 3 times a day on an empty stomach 1.5-2 hours before meals; rectally - once a day (liquid in the form of enemas or suppositories). With intestinal dysbiosis, treatment is carried out for 7-10 days under bacteriological control. For children of the first days of life, in the first two doses, the staphylococcal bacteriophage is diluted with boiled water 2 times. In the absence of adverse reactions (regurgitation, rash on the skin), the undiluted drug is used in the future. In this case, it can be mixed with breast milk.
For sepsis, enterocolitis of newborns, including premature babies, staphylococcal bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day. A combination of rectal (in enemas) and oral (oral) administration of the drug is possible.
In the treatment of omphalitis, pyoderma, infected wounds in newborns, staphylococcal bacteriophage is used in the form of applications twice daily (a gauze napkin is moistened with staphylococcal bacteriophage and applied to the umbilical wound or to the affected area of the skin).
Recommended dosage of Staphylococcal Bacteriophage:
Age 1 dose Orally liquid In enema (ml) Up to 6 months 5-10 ml 20 From 6 to 12 months 10-15 ml 20 From 1 year to 3 years 15-20 ml 40 From 3 to 8 years 20-50 ml 40-100 From 8 years and older 20-50 ml 40-100 The frequency of taking a liquid preparation - 2-3 times a day.
Staphylococcal bacteriophage is used for prophylaxis in an amount of 50 ml. for irrigation of postoperative wounds, etc.
In order to prevent sepsis and enterocolitis in newborns with intrauterine infection or the risk of nosocomial infection, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.
Staphylococcal liquid bacteriophage is not suitable for use with turbidity and the presence of flakes.