Sumamed, 500 mg teva 3 pcs.

$13.00 - $18.00
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Product Description

Structure

1 tablet contains 500 mg azithromycin dihydrate

pharmachologic effect

The antibiotic of the macrolide group is azalide. It has a wide range of antimicrobial effects. It binds to the 50S subunit of the ribosome, inhibits the biosynthesis of protein microorganisms. In high concentrations it has a bactericidal effect.

Azithromycin is active against gram-positive aerobic bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, streptococcus groups C, F and G, Staphylococcus aureus, Staphylococcus epidermidis; some gram-positive anaerobic bacteria: Clostridium perfringens.

Azithromycin is active against gram-negative aerobic bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Neisseria gonorrhoeae, Neisseria meningi bacterididis, Campini

Azithromycin is also active against intracellular and other microorganisms: Mycobacterium avium complex, Legionella pneumophila, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Ureaplasma urealyticum, Listeria monocitogenes, Borrelia burgdorferiallidum, Treponema.

Gram-positive bacteria resistant to erythromycin are resistant to the drug.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
  - infections of the upper respiratory tract and ear (bacterial pharyngitis, tonsillitis, sinusitis, otitis media);
  - lower respiratory tract infections (bacterial bronchitis, interstitial and alveolar pneumonia, exacerbation of chronic bronchitis);
  - infections of the skin and soft tissues (chronic erythema migrans - the initial stage, Lyme disease, erysipelas, impetigo, secondary dermatoses);
  - Sexually transmitted infections (urethritis, cervicitis);
  - diseases of the stomach and duodenum associated with Helicobacter pylori.

Pregnancy and lactation

During pregnancy, the drug should be administered only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to administer Sumamed to women during lactation, it is necessary to decide on the termination of breastfeeding.

Contraindications

- severe violations of the liver and kidneys;
 - Hypersensitivity to antibiotics of the macrolide group;

Precautions: during pregnancy and lactation, with impaired liver and kidney function, patients with impaired or predisposed to arrhythmias and lengthening of the QT interval.

Side effects

They are rare (in 1% of cases or less).

From the digestive system: melena, cholestatic jaundice, nausea, vomiting, diarrhea, constipation, loss of appetite, gastritis, reversible moderate increase in the activity of liver enzymes.

From the urinary system: jade.

From the reproductive system: vaginal candidiasis.

From the cardiovascular system: palpitations, chest pain.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, vertigo, drowsiness, increased fatigue; in children - headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbances.

Allergic reactions: skin rashes, Quincke's edema, urticaria, conjunctivitis.

Dermatological reactions: photosensitivity, pruritus.

On the part of laboratory indicators: in some cases - neutrophilia, eosinophilia (altered indicators return to normal 2-3 weeks after discontinuation of treatment).

Interaction

Antacids (containing aluminum, magnesium), ethanol and food intake significantly reduce the absorption of azithromycin (capsules and suspension), so the drug should be taken at least 1 hour before or 2 hours after taking these drugs and food.
Azithromycin, unlike other macrolide antibiotics, does not bind to isoenzymes of the cytochrome P 450 system . To date, there has been no interaction with theophylline, terfenadine, carbamazepine, triazolam, digoxin.

While taking macrolides with cycloserine, indirect anticoagulants, methylprednisolone, felodipine and microsomal oxidation preparations (cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramidum, bromocriptine, phenytoin toxicity, peroxidation, peroxidation, peroxidation, peroxidation, peroxidine, , while the use of azalides such interaction to date has not been observed.

If necessary, co-administration with warfarin, it is recommended to carefully monitor the prothrombin time.
With the simultaneous administration of macrolides with ergotamine and dihydroergotamine, their toxic effects (vascular spasm, dysesthesia) are possible.

Lincosamines reduce, and tetracycline and chloramphenicol increase the effectiveness of azithromycin.

Pharmaceutically, azithromycin is incompatible with heparin.

How to take, course of administration and dosage

The drug is prescribed orally 1 time per day. The bioavailability of the drug in tablet form does not depend on food intake.

Children 6 months and older are recommended to use the drug in the form of a suspension for oral administration or 125 mg tablets

For infections of the upper and lower respiratory tract, skin and soft tissues (except for chronic migratory erythema),
adults are prescribed a dose of 500 mg 1 time / day for 3 days, a course dose of 1.5 g.
Children are prescribed at a rate of 10 mg / kg body weight 1 time / day for 3 days, course dose - 30 mg / kg.

In chronic erythema migrans: for
adults, the drug is prescribed 1 time / day for 5 days: 1 day - 1 g (2 tablets, 500 mg each), then from 2 to 5 days - 500 mg each, a course dose of 3 g.
Children are prescribed 1 day at a dose of 20 mg / kg body weight and then from 2 to 5 days - daily at a dose of 10 mg / kg body weight, course dose of 60 mg / kg.

In diseases of the stomach and duodenum associated with Helicobacter pylori,
1 g (2 tablets of 500 mg) is prescribed per day for 3 days in combination with an antisecretory agent and other drugs.

In
case of sexually transmitted infections, a dose of 1 g is prescribed once for the treatment of uncomplicated urethritis / cervicitis;
for the treatment of complicated long-lasting urethritis / cervicitis caused by Chlamydia trachomatis, 1 g 3 times is prescribed with an interval of 7 days (1, 7, 14 days), the course dose is 3 g

Overdose

Symptoms: nausea, vomiting, diarrhea, temporary hearing loss.

Treatment: symptomatic.

Special instructions

If you miss one dose of the drug, the missed dose should be taken as soon as possible, and the next ones should be taken at intervals of 24 hours.

The patient should be warned about the need to inform the doctor about the occurrence of any side effect.

Release form

Tablets

Storage conditions

Keep out of reach of children at temperatures between 15 ° and 25 ° C.

Shelf life

3 years.

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