Urofuragin 50 mg, 30 pcs.

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Product Description


1 tab.:

Furazidine 50 mg

Excipients: corn starch - 27.5 mg, sucrose - 13.75 mg.

pharmachologic effect

Antimicrobial agent with a wide spectrum of action, belongs to the group of nitrofurans. The mechanism of action is associated with inhibition of nucleic acid synthesis. Under the influence of nitrofurans, there is a suppression of the activity of the respiratory chain and the tricarboxylic acid cycle (Krebs cycle), as well as the inhibition of other biochemical processes of microorganisms, which leads to the destruction of their membrane or cytoplasmic membrane.

Active against gram-positive cocci: Staphylococcus spp., Streptococcus spp .; gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.
Resistant to furazidine: Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., Most strains of Proteus spp., Serratia spp.

Depending on the concentration, it has a bactericidal or bacteriostatic effect. Against most bacteria, the bacteriostatic concentration is from 10 to 20 μg / ml. The bactericidal concentration is about 2 times higher.



Absorbed from the small intestine by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds absorption from the proximal and medial segment by 2 and 4 times, respectively. Poorly absorbed from the colon. Cmax in blood serum lasts from 3 to 7-8 hours.


Distributed evenly.
In high concentrations found in lymph; in bile, its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower than in serum; saliva contains up to 30% of its concentration in serum; the concentration in blood and tissues is small, which is associated with its rapid excretion, while its concentration in urine is much higher than in blood.

Metabolism and excretion

Metabolized in the liver (less than 10%), with a decrease in renal excretory function, the metabolic rate increases.

It is found in urine after 3-4 hours. Does not change the pH of urine, unlike nitrofurantoin.

It is excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially subjected to reverse reabsorption in the tubules.
At low concentrations in the urine, the filtration and secretion process predominates, at high concentrations, secretion decreases and reabsorption increases.
Being a weak acid, it does not dissociate; at acidic pH values, urine undergoes intensive reabsorption, which can enhance systemic side effects.


- treatment of infectious and inflammatory diseases of the urinary tract (cystitis, urethritis, pyelonephritis) caused by microorganisms sensitive to furazidine;
- prevention of infectious complications after surgical interventions on the genitourinary system.


- impaired renal function;

- urosepsis and kidney parenchyma infections;

- impaired liver function;

- pregnancy;

- period of breastfeeding;

- children's and teenage age up to 18 years;

- deficiency of lactase, sucrose / isomaltase, lactose intolerance, fructose, glucose-galactose malabsorption;

- Hypersensitivity to furazidine, other components of the drug;

- Hypersensitivity to nitrofuran derivatives.

With caution, the drug should be prescribed for anemia, lung diseases (especially in patients over 65), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of glucose-6-phosphate dehydrogenase, group B vitamins and folic acid.

Side effects

From the hemopoietic system:  agranulocytosis, thrombocytopenia, aplastic anemia, eosinophilia.

From the nervous system:  dizziness, headache, drowsiness, weakness, peripheral neuropathy, the development of polyneuritis.

From the side of the organ of vision:  visual impairment.

From the cardiovascular system:  intracranial hypertension.

From the respiratory system:  shortness of breath, chest pain, cough with and without sputum, interstitial pneumonitis, pulmonary fibrosis.

From the digestive system : nausea, vomiting, decreased appetite, anorexia, diarrhea, pancreatitis, impaired liver function, cholestatic jaundice, hepatitis.

From the musculoskeletal system : myalgia, arthralgia.

From the skin and subcutaneous tissues:  skin rash (including papular), enanthema, pruritus, exfoliative dermatitis, reversible alopecia.

Allergic reactions:  angioedema, urticaria, erythema multiforme.

Other:  fever.


With simultaneous use with ristomycin, chloramphenicol, sulfonamides, the risk of hematotoxic effects increases.

The simultaneous use of other nitrofuran derivatives, as well as drugs that acidify urine (including ascorbic acid, calcium chloride), should be avoided.

Urine alkalizing drugs accelerate the excretion of furazidine in the urine.
Ethanol can increase the severity of side effects.
Probenecid and sulfinpyrazone decrease urinary excretion of furazidine.

This can lead to cumulation of furazidine and increase its toxicity.
With the simultaneous use of magnesium-containing antacids, the absorption of furazidine decreases.

How to take, course of administration and dosage

The drug is taken orally after a meal.

For treatment, 100-200 mg is used 2-3 times / day for 7-10 days. If necessary, after a 10-15-day break, treatment courses are repeated. The maximum daily dose is 600 mg.

For the prevention of infectious complications after surgical interventions on the organs of the genitourinary system, 50 mg is used once 30 minutes before surgery.


Symptoms: neurotoxic reactions, polyneuritis, impaired liver function, acute toxic hepatitis.

Treatment: drug withdrawal, large fluid intake, symptomatic therapy, antihistamines, B vitamins.

There is no specific antidote.

Special instructions

To prevent the development of side effects, a heavy drink is prescribed.

To prevent the development of neuritis, it is necessary to prescribe B vitamins.

When using the drug, urine stains in brown.

With prolonged use of the drug, it is necessary to monitor the picture of peripheral blood, kidney, liver and lung function.

False positive results are possible when determining glucose in the urine using enzymatic methods.

When using the drug, it is possible to develop diarrhea caused by Clostridium difficile (pseudomembranous colitis).

 In mild cases, discontinuation of the drug is sufficient; in severe cases, appropriate treatment should be prescribed.

Do not use drugs that inhibit intestinal motility.

Impact on the ability to drive vehicles and control mechanisms

During the treatment period, one should refrain from driving vehicles and engaging in other activities that require an increased concentration of attention and speed of psychomotor reactions.

Release form

The tablets are yellow-orange in color, round, flat-cylindrical, with a notch on one side and a bevel on both sides.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.

Shelf life

3 years. Do not use after expiration date.

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